A CpG oligonucleotide can protect mice from a low aerosol challenge dose of Burkholderia mallei.
نویسندگان
چکیده
Treatment with an oligodeoxynucleotide (ODN) containing CPG motifs (CpG ODN 7909) was found to protect BALB/c mice from lung infection or death after aerosol challenge with Burkholderia mallei. Protection was associated with enhanced levels of gamma interferon (IFN-gamma)-inducible protein 10, interleukin-12 (IL-12), IFN-gamma, and IL-6. Preexposure therapy with CpG ODNs may protect victims of a biological attack from glanders.
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ورودعنوان ژورنال:
- Infection and immunity
دوره 74 3 شماره
صفحات -
تاریخ انتشار 2006